Phenotype Image Detail

Image

Caption

Gross pathology of intestinal tract. A and B: Intestinal tract of a 23 day old Slc12a2^tm1Ges/Slc12a2^tm1Ges mouse with blood in the cecum (A) and severe blockage of the colon (A and B). The single arrow indicates the cecum, double arrows indicate the colon, and arrowheads indicate the small intestine. C: Small intestine, cecum and colon of a 26 day old mutant mouse. Note blood in the small intestine and in the wormlike cecum. D and E: Intestinal tract of a 13 month old mutant mouse. Note the wormlike extension (asterisk in D) of the cecum and severe obstructions of the cecum (D) and colon (E) by feces. F: Intestinal tract of a 21 day old Slc12a2^tm1Ges/Slc1212⁺ mouse having blood in the lumen of its cecum, obstruction of both cecum and colon by feces, intussusception of the small intestine (at the site marked by the arrowhead), and a wormlike extension (asterisk) of its cecum.

Copyright

This image is from Flagella M, J Biol Chem 1999 Sep 17;274(38):26946-55 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:57651

Associated Alleles

Symbol	Name
Slc12a2^tm1Ges	solute carrier family 12, member 2; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc12a2^tm1Ges/Slc12a2^tm1Ges	Not Specified
Slc12a2^tm1Ges/Slc12a2^tm1Ges	involves: NMRI
Slc12a2^tm1Ges/Slc12a2^tm1Ges	FVB.129(Cg)-Slc12a2^tm1Ges