Phenotype Image Detail

Image

Caption

Sections of the stria vascularis of wild type (+/+, A) and Slc12a2^tm1Ges/Slc12a2^tm1Ges (-/-, B) mice. In the wild type, marginal cells (M) are in contact with the endolymph of the scala media (SM). In the mutant, Reissner's membrane (RM), bordered on the left by the scala vestibuli (SV), is pressed against the marginal cell layer. Mutant marginal cells have fewer extensions of their basal surfaces than those of wild type mice. The intercellular spaces between the marginal cell layer and deeper layers of the stria vascularis are wider in mutant than in wild type ears. Basal cells (B) are present in both genotypes. Scale bar: 25um.

Copyright

This image is from Flagella M, J Biol Chem 1999 Sep 17;274(38):26946-55 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:57651

Associated Alleles

Symbol	Name
Slc12a2^tm1Ges	solute carrier family 12, member 2; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc12a2^tm1Ges/Slc12a2^tm1Ges	Not Specified
Slc12a2^tm1Ges/Slc12a2^tm1Ges	involves: NMRI
Slc12a2^tm1Ges/Slc12a2^tm1Ges	FVB.129(Cg)-Slc12a2^tm1Ges