Phenotype Image Detail

Image

Caption

Hematoxylin and eosin stained sections of gastric epithelium of 9 week old wild type (+/+, A) and Slc9a4^tm1Ges/Slc9a4^tm1Ges (-/-, B and C) mice. As compared with wild type, the glandular stomach of mutant mice was characterized by reduction in the number of readily discernable parietal and chief cells and an increase in the number of mucous and relatively undifferentiated cells. When observed under increased magnification, compared with wild type glandular stomach (D), the mutant stomach (E) exhibited decreased cell size and an increase in interglandular connective tissue (arrows). Scale bar, 50um.

Copyright

This image is from Gawenis LR, J Biol Chem 2005 Apr 1;280(13):12781-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:98566

Associated Alleles

Symbol	Name
Slc9a4^tm1Ges	solute carrier family 9 (sodium/hydrogen exchanger), member 4; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc9a4^tm1Ges/Slc9a4^tm1Ges	involves: 129S6/SvEvTac * Black Swiss