Phenotype Image Detail

Image

Caption

Histology of parietal cells from wild type and Slc9a4^tm1Ges/Slc9a4^tm1Ges mice at 9 weeks of age. A: Wild type (+/+) parietal cells. Arrows indicate secretory canaliculi. B: Typical Slc9a4^tm1Ges/Slc9a4^tm1Ges parietal cells often had a single nidus of canalicular membranes (arrow), which was usually restricted to the apical pole of the cell. C: A small subset of mutant parietal cells exhibited larger canaliculi (arrow) suggestive of more active acid secretion. D: Necrotic, highly vacuolated cells (N) were often observed in mutant gastric glands. E: Mutant gastric glands contained more cells with the condensed chromatin (arrow) characteristic of apoptosis. Scale bar in A, 20um.

Copyright

This image is from Gawenis LR, J Biol Chem 2005 Apr 1;280(13):12781-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:98566

Associated Alleles

Symbol	Name
Slc9a4^tm1Ges	solute carrier family 9 (sodium/hydrogen exchanger), member 4; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc9a4^tm1Ges/Slc9a4^tm1Ges	involves: 129S6/SvEvTac * Black Swiss