Phenotype Image Detail

Image

Caption

Electron micrographs of mucous and undifferentiated cells from 9 week old wild type (+/+) and Slc9a4^tm1Ges/Slc9a4^tm1Ges (-/-) mice. A: Wild type mucous pit cell showing mucus granules. B: Mutant mucous pit cells had mucus granules and small cystic structures (arrow) were often observed as well. C: In mutant gastric glands, one of the most common cell types observed by electron microscopy was a relatively undifferentiated cell with numerous polysomes and none of the ultrastructural features indicative of a specific lineage. The cytoplasm of some of these cells (arrows) appeared ligher than others (see adjacent cells). Abbreviations: N, nucleus. Scale bar: 5um.

Copyright

This image is from Gawenis LR, J Biol Chem 2005 Apr 1;280(13):12781-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:98566

Associated Alleles

Symbol	Name
Slc9a4^tm1Ges	solute carrier family 9 (sodium/hydrogen exchanger), member 4; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc9a4^tm1Ges/Slc9a4^tm1Ges	involves: 129S6/SvEvTac * Black Swiss