Phenotype Image Detail

Image

Caption

A: Coronal sections of brains from wild type (B⁺/B⁺), Myh10^tm2Rsad/Myh10^tm2Rsad (B^-/B^-) (postnatal day 0(P0)) and Myh10^{tm6(Myh9/GFP)Rsad}/Myh10^{tm6(Myh9/GFP)Rsad} (B^a*/B^a*) (postnatal day 4 (P4)) mice. Note that in the Myh10^tm2Rsad/Myh10^tm2Rsad mouse brain, the lateral ventricles are enlarged due to severe hydrocephalus. Scale bar: 100um. B: Cross-sections of spinal cords at the thoracic level of wild type, Myh10^tm2Rsad/Myh10^tm2Rsad, and Myh10^{tm6(Myh9/GFP)Rsad}/Myh10^{tm6(Myh9/GFP)Rsad} mice at E12.5. Note that the spinal canal is patent in wild type and Myh10^{tm6(Myh9/GFP)Rsad}/Myh10^{tm6(Myh9/GFP)Rsad} mice. In contrast, the spinal canal is obstructed in Myh10^tm2Rsad/Myh10^tm2Rsad mice. The middle panel in B is reprinted with permission from Ma et al. (36). Scale bar, 100um.

Copyright

This image is from Bao J, J Biol Chem 2007 Jul 27;282(30):22102-11 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:124610

Associated Alleles

Symbol	Name
Myh10^tm2Rsad	myosin, heavy polypeptide 10, non-muscle; targeted mutation 1, Robert S Adelstein
Myh10^tm6(Myh9/GFP)Rsad	myosin, heavy polypeptide 10, non-muscle; targeted mutation 6, Robert S Adelstein

Associated Genotypes

Allelic Composition	Genetic Background
Myh10^tm2Rsad/Myh10^tm2Rsad	involves: 129S4/SvJae
Myh10^tm6(Myh9/GFP)Rsad/Myh10^tm6(Myh9/GFP)Rsad	involves: 129S6/SvEvTac * C57BL/6