Phenotype Image Detail

Image

Caption

Histology of wild type and Slc4a4^tm1Ges/Slc4a4^tm1Ges spleen. Spleens of both genotypes were stained with hematoxylin and eosin and examined by light microscopy. Relative to wild type spleen (A), which exhibited normal organization of red pulp (R) and white pulp (W), Slc4a4^tm1Ges/Slc4a4^tm1Ges spleen (B) exhibited poor organization with many areas that could not be clearly delineated into red pulp and white pulp. At higher magnification of wild type (C) and mutant (D) spleens, the predominance of lymphocytes and smaller size of megakaryocytes (arrows) was apparent in mutants. Scale bars: A and B, 200um; C and D, 100um.

Copyright

This image is from Gawenis LR, J Biol Chem 2007 Mar 23;282(12):9042-52 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:120867

Associated Alleles

Symbol	Name
Slc4a4^tm1Ges	solute carrier family 4 (anion exchanger), member 4; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc4a4^tm1Ges/Slc4a4^tm1Ges	involves: 129S6/SvEvTac * Black Swiss