Phenotype Image Detail

Image

Caption

Magnetic resonance images of brains. Parasagittal of brains from a normal littermate (EF5 +/+) and Ank2^tm1Bnt/Ank2^tm1Bnt (-/-) mouse are in red boxes on the right. Sections indicated by blue and green lines are displayed on the left. Although unmyelinated, the internal capsule and pyramidal tracts are clearly visible in the normal brain (top left, blue and green panels) and were not evident in the mutant (bottom left, blue and green panels). The internal capsule and corpus callosum are also visualized in the parasagittal sections of the normal brain (top right, red panel) and could not be resolved in the mutant (bottom right, red panel). The lateral ventricles were abnormally enlarged in the mutant brains (bottom left, blue panel).

Copyright

This image is from Scotland P, J Cell Biol 1998 Nov 30;143(5):1305-15, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:52124

Associated Alleles

Symbol	Name
Ank2^tm1Bnt	ankyrin 2, brain; targeted mutation 1, Vann Bennett

Associated Genotypes

Allelic Composition	Genetic Background
Ank2^tm1Bnt/Ank2^tm1Bnt	involves: 129X1/SvJ * C57BL/6