Phenotype Image Detail

Image

Caption

Analysis of skeletons by Alizarin red/Alcian blue staining. Calcified tissues are stained red with Alizarin red and cartilage is stained blue with Alcian blue. A: Whole skeleton. B: Superior view of the skull. C: Hyoid bone. D: Clavicles. E: Sternum with ribs. F: Scapula and forelimb skeletons. G: Caudal vertebrae. Compared with the wild type (+/+) the Runx2^tm1Ldq/Runx2^tm1Ldq (-/-) mice have defects in the posterior of the formation of specific cranial bones, particularly the basal part of the skull that is formed through endochondral ossification, as well as the distal appendicular and axial skeletons that form during the later stage of skeletogenesis (indicated by arrows). The Runx2^tm1Ldq/Runx2⁺ (+/-) mice had no gross skeletal abnormalities.

Copyright

This image is from Xiao ZS, J Biol Chem 2004 May 7;279(19):20307-13 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:89822

Associated Alleles

Symbol	Name
Runx2^tm1Ldq	runt related transcription factor 2; targeted mutation 1, L Darryl Quarles

Associated Genotypes

Allelic Composition	Genetic Background
Runx2^tm1Ldq/Runx2^tm1Ldq	involves: C57BL/6J