Phenotype Image Detail

Image

Caption

A: Lens opacity in Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} (-/-) mice. Total and partial lens opacity and iris cornea adhesion are detected in mutant mice. B: Histological analysis shows abnormal lens fibers in the lens cortical zone of mutant mice. Abnormal protein deposit is also detected (arrow) (32). C: Statistical analysis shows mutants have smaller lens compared with wild type (+/+) mice. D: The ratio of soluble and insoluble alphaA-crystallin has been changed in mutant mice with significant increase of insoluble alphaA-cyrstallin in mutant mice. E: Activation of alphaA-crystallin promoter reporter by Lgr4 active mutant T7551. F: Ganglion cells loss and thinning of inner and outer nuclear layers in mutant mice at 6 months of age. Scale bars: B, 340um; F, 100um.

Copyright

This image is from Weng J, Proc Natl Acad Sci U S A 2008 Apr 22;105(16):6081-6. Copyright 2008 National Academy of Sciences, U.S.A. J:134299

Associated Alleles

Symbol	Name
Lgr4^Gt(LST020)Byg	leucine-rich repeat-containing G protein-coupled receptor 4; gene trap LST020, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Lgr4^Gt(LST020)Byg/Lgr4^Gt(LST020)Byg	involves: 129P2/OlaHsd * C57BL/6