Phenotype Image Detail

Image

Caption

Abnormalities exhibited by Has2^tm1Jam/Has2^tm1Jam embryos. A: Yolk sac of an Has2^tm1Jam/Has2⁺ (+/-) embryo. B: Yold sac from an Has2^tm1Jam/Has2^tm1Jam (-/-) littermate. Cross-sections of the yolk sac stained with hematoxylin and eosin are show in the inset. Note the presence of vitelline vessels (VV) containing nucleated red blood cells in the yolk sac of the heterozygous embryo. The endoderm and mesoderm are not fused in the homozygous embryo, and the red blood cells are free within this space. C and D: Representative wild type and mutant embryos at E9.5. Note the diminished size, the bloodless heart, and distorted somites of the mutant embryo. E and F: E9.5 wild type and mutant embryos stained for the endothelial marker PECAM. Note the absence of an organized vascular network expressing PECAM in the mutant embryo. P, pericardium; E, endoderm; M, mesoderm; OpP, optic placode; OtP, otic placode; first and second pharyngeal pouches are numbered. Scale bars in C-F, 500um.

Copyright

This image is from Camenisch TD, J Clin Invest 2000 Aug;106(3):349-60 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:63748

Associated Alleles

Symbol	Name
Has2^tm1Jam	hyaluronan synthase 2; targeted mutation 1, John A McDonald

Associated Genotypes

Allelic Composition	Genetic Background
Has2^tm1Jam/Has2^tm1Jam	involves: 129P2/OlaHsd * C57BL/6J