Phenotype Image Detail

Image

Caption

The cardiac jelly of wild type embryos is rich in acidic glycosaminoglycans (blue stain in A) and hyaluronic acid (HA, brown stain in C). In contrast, Has2^tm1Jam/Has2^tm1Jam embryos totally lack alcian blue-stained material (B) and HA (D). The heart of the mutant embryo has a characteristic constriction at the atrioventricular (AV) canal region (indicated by arrows), but no endocardial cushions, which are indicated by the asterisks in A and C. Scale bars: A and B, 100um; C and D, 250um.

Copyright

This image is from Camenisch TD, J Clin Invest 2000 Aug;106(3):349-60 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:63748

Associated Alleles

Symbol	Name
Has2^tm1Jam	hyaluronan synthase 2; targeted mutation 1, John A McDonald

Associated Genotypes

Allelic Composition	Genetic Background
Has2^tm1Jam/Has2^tm1Jam	involves: 129P2/OlaHsd * C57BL/6J