Phenotype Image Detail

Image

Caption

Histology of oral mucous membranes and skin in Dsg3^tm1Stan/Dsg3^tm1Stan mice and human Pemphigus Vulgaris patients. A: Dsg3^tm1Stan/Dsg3^tm1Stan: inflammatory oral erosion of the tongue. B: Human Pemphigus Vulgaris (PV): inflammatory oral erosion. C: Mutant: oral lesion shows basal cells are separated from each other and the suprabasilar epithelium is lost. This is a characteristic histology called a "row of tombstones." D: Human PV: oral lesion shows a "row of tombstones." E: Mutant: early oral lesions show suprabasilar acantholysis with intact suprabasilar epithelium separated from basal cells. F: Mutant: early skin lesion on dorsum of foot near where skin was traumatized by cutting. G: Human PV: skin lesion shows typical suprabasilar acantholysis. Bar: A and B, 160um; C-G, 40um.

Copyright

This image is from Koch PJ, J Cell Biol 1997 Jun 2;137(5):1091-102, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:40804

Associated Alleles

Symbol	Name
Dsg3^tm1Stan	desmoglein 3; targeted mutation 1, John R Stanley

Associated Genotypes

Allelic Composition	Genetic Background
Dsg3^tm1Stan/Dsg3^tm1Stan	involves: 129X1/SvJ * C57BL/6J