Phenotype Image Detail

Image

Caption

Gross histology of Itgb2^tm2Bay/Itgb2^tm2Bay mice. C: Ulcerative dermatitis with full thickness necrosis of the epidermis covered by an eosinophilic crust with entrapped inflammatory cells and bacterial colonies (arrows). There is adjacent epidermal hyperplasia. The dermal inflammatory infiltrate consists of lymphocytes, histiocytes, mast cells, occasional plasma cells and few neutrophils. E, epidermis; D, dermis; U, ulceration. Original magnification 250x. The slpeen shown in D with hyperplasia of the red pulp, multiple plasma cells (*), and occasional Russell bodies (arrows), the latter indicative of abnormal deposition of immunoglobulins within plasma cells. Original magnification 400x.

Copyright

This image is from Scharffetter-Kochanek K, J Exp Med 1998 Jul 6;188(1):119-31, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License J:48542

Associated Alleles

Symbol	Name
Itgb2^tm2Bay	integrin beta 2; targeted mutation 2, Baylor College of Medicine

Associated Genotypes

Allelic Composition	Genetic Background
Itgb2^tm2Bay/Itgb2^tm2Bay	involves: 129S7/SvEvBrd * C57BL/6J