Phenotype Image Detail

Image

Caption

A: Wild type (WT) and Rock1^tm1Sna/Rock1^tm1Sna (KO) embryos at 18.5dpc. Arrowheads and arrows indicate eyes open at birth (EOB) and omphalocele phenotypes, respectively. Severe, moderate and mild forms of omphalocele in the mutant embryos are shown from left to right. B: Eyes of wild type and mutant mice at 18.5dpc. The eyes of the mutant embryos are either fully open (middle) or partially open (right; arrow indicates small hole). C: Eyes of adult wild type and mutant mice. D: Umbilical region of wild type and mutant neonates. The umbilical ring in wild type neonate is closed (arrowhead), whereas that in the mutant neonate remains open (arrow). E: Visceral organs in the abdominal cavity of the neonates shown in D. The ventral body wall was removed to render the visceral organs visible. Portions of the liver and intestine are absent in the mutant neonate. F: Gastrointestinal tract from the stomach to the colon of the neonates shown in D and E. A part of the small intestine is absent in the mutant mouse.

Copyright

This image is from Shimizu Y, J Cell Biol 2005 Mar 14;168(6):941-53, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:98250

Associated Alleles

Symbol	Name
Rock1^tm1Sna	Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1, Shuh Narumiya

Associated Genotypes

Allelic Composition	Genetic Background
Rock1^tm1Sna/Rock1^tm1Sna	B6N.129X1-Rock1^tm1Sna