Phenotype Image Detail

Image

Caption

Mason trichrome (A and B) and orcein (C and D), and alpha-smooth muscle actin immunostaining (E and F) are shown from lung tissue at 6 months of age in wild type (A,C and E) and Sftpc^tm1Swg/Sftpc^tm1Swg (B,D and F) littermates. Extensive airspace remodeling with monocytic infiltration and dense blue staining was observed (arrows). Orcein staining demonstrated that elastin fibers were absent in many of the remodeled airspaces (D). Smooth muscle actin staining was observed in alveolar regions of the lung parenchyma in mutant (arrows) but not wild type mice.

Copyright

This image is from Glasser SW, J Biol Chem 2003 Apr 18;278(16):14291-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:82925

Associated Alleles

Symbol	Name
Sftpc^tm1Swg	surfactant associated protein C; targeted mutation 1, Stephan W Glasser

Associated Genotypes

Allelic Composition	Genetic Background
Sftpc^tm1Swg/Sftpc^tm1Swg	either: 129 or (involves: 129 * Black Swiss)
Sftpc^tm1Swg/Sftpc^tm1Swg	involves: 129/Sv * Black Swiss