Phenotype Image Detail

Image

Caption

Electron microscopy was performed on Sftpc^tm1Swg/Sftpc^tm1Swg mice at 9 months of age. Marked abnormalities were observed in the alveolar walls from mutant mice (A). Type II cells were hyperplastic, containing numerous lamellar body-like inclusions, and collagen deposition was noted within the alveolar walls. Alveolar capillaries were surrounded by thickened subepithelial stroma. Conducting airways were lined by dysplastic epithelial cells with atypical morphology (B). Numerous cytopathic dense organelles, likely representing atypical mitochondria, were observed in nonciliated columnar epithelial cells. Alveolar macrophages were hyperplastic, some containing dense crystals (top cell, C). Others containing excessive amounts of surfactant lipids, including lamellar bodies and tubular myelin figures, were observed. Pulmonary vascular abnormalities were observed in small vessels in mutant mice. Vessels were occluded or absent in many alveoli. Abnormal membrane blebbing was recurrently observed along the intima of the abnormal vessels (D).

Copyright

This image is from Glasser SW, J Biol Chem 2003 Apr 18;278(16):14291-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:82925

Associated Alleles

Symbol	Name
Sftpc^tm1Swg	surfactant associated protein C; targeted mutation 1, Stephan W Glasser

Associated Genotypes

Allelic Composition	Genetic Background
Sftpc^tm1Swg/Sftpc^tm1Swg	either: 129 or (involves: 129 * Black Swiss)
Sftpc^tm1Swg/Sftpc^tm1Swg	involves: 129/Sv * Black Swiss