Phenotype Image Detail

Image

Caption

Conducting airways from wild type (A and C) and Sftpc^tm1Swg/Sftpc^tm1Swg (B and D) mice are observed after hematoxylin and eosin staining (A and B) or MUC5A/C immunohistochemistry (C and D). Marked epithelial cell dysplasia was observed in large and small conducting airways of mutant mice. The abnormal epithelial cells were hypertrophic with abnormal foci of pseudostratified epithelia. Whereas MUC5A/C staining cells were rarely seen in wild type mice (C), extensive staining for MUC5A/C was observed throughout bronchi and bronchioles (D) and was occasionally observed in the peripheral lung parenchyma in mutant mice (not shown). Magnification: A and B, x625; C and D, x1250.

Copyright

This image is from Glasser SW, J Biol Chem 2003 Apr 18;278(16):14291-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:82925

Associated Alleles

Symbol	Name
Sftpc^tm1Swg	surfactant associated protein C; targeted mutation 1, Stephan W Glasser

Associated Genotypes

Allelic Composition	Genetic Background
Sftpc^tm1Swg/Sftpc^tm1Swg	either: 129 or (involves: 129 * Black Swiss)
Sftpc^tm1Swg/Sftpc^tm1Swg	involves: 129/Sv * Black Swiss