Phenotype Image Detail

Image

Caption

Three month old mice were used for experiments of high fat feeding. Apoe^tm1Unc/Apoe^tm1Unc and Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc mice were fed high fat diet A for 8 weeks; Ldlr^tm1Her/Ldlr^tm1Her and Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her mice were fed high fat diet B for 8 weeks. Apoe^tm1Unc/Apoe^tm1Unc (A) and Ldlr^tm1Her/Ldlr^tm1Her (B) mice had normal epidermal and dermal structure with substantial subcutaneous adipose tissue. No foam cells were observed. In Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc (C and E) and Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her (D and F) mice, the dermal layers were extensively infiltrated with fat-laden macrophage (foam cells). Acellular necrotic areas with cholesterol clefts were present. There was a reduced number of hair follicles. Note that subcutaneous adipose tissue was not discernible. High magnification of the dermal layer of Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc (E) and Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her (F) mice is shown. Many macrophages exhibited multinucleated giant cell appearance with eosinophilic cytoplasms.

Copyright

This image is from Yagyu H, J Biol Chem 2000 Jul 14;275(28):21324-30 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:63468

Associated Alleles

Symbol	Name
Apoe^tm1Unc	apolipoprotein E; targeted mutation 1, University of North Carolina
Ldlr^tm1Her	low density lipoprotein receptor; targeted mutation 1, Joachim Herz
Soat1^tm1Ishi	sterol O-acyltransferase 1; targeted mutation 1, Shun Ishibashi

Associated Genotypes

Allelic Composition	Genetic Background
Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her	involves: 129S7/SvEvBrd * C57BL/6