Phenotype Image Detail

Image

Caption

Ultrathin-section electron micrographs of stereocilia of cochlear outer hair cells of wild type and Rdx^tm1Sts/Rdx^tm1Sts mice at 3 weeks of age. A: Low power electron micrographs. All of the wild type (Rdx^+/+) hair cells bear numerous stereocilia with normal appearance, whereas Rdx^tm1Sts/Rdx^tm1Sts (Rdx^-/-) hair cells were frequently characterized by abnormal 1-3 residual knoblike cellular protrusions on their apical surfaces. B: Wild type radixin-based stereocilia (A) and mutant ezrin-based stereocilia at various degeneration stages (B-D). Mutant ezrin-based stereocilia contained highly organized bundles of actin filaments as cores (B) that were indistinguishable in appearance from those in wild type radixin-based stereocilia (A), and during the process of degeneration, these stereocilia as well as core bundles appeared to be fused to form abnormal thick and short protrusions (C and D). Bars, 0.5um.

Copyright

This image is from Kitajiri S, J Cell Biol 2004 Aug 16;166(4):559-70, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:124151

Associated Alleles

Symbol	Name
Rdx^tm1Sts	radixin; targeted mutation 1, Shoichiro Tsukita

Associated Genotypes

Allelic Composition	Genetic Background
Rdx^tm1Sts/Rdx^tm1Sts	involves: 129S4/SvJae * C57BL/6