Phenotype Image Detail

Image

Caption

Developmental cardiovascular defects of Ramp2^tm1Kmca/Ramp2^tm1Kmca embryos phenocopies those of Calcrl^tm1Kmca/Calcrl^tm1Kmca and Adm^tm1Unc/Adm^tm1Unc embryos. Histological sections from E14.5 wild type (WT) and Ramp2^tm1Kmca/Ramp2^tm1Kmca (RAMP2^-/-) embryos stained with hematoxylin and eosin. The mutant embryos had generally smaller hearts than wild type littermates (A,B) with overtly normal artia, ventricles, valves and septum. The thickness of the compact zone of the right ventricle (RV) was significantly diminished in mutant embryos compared to wild type littermate controls (C,D). While the endothelial lining of aortas (Ao) from mutant embryos appeared indistinguishable from that of wild type littermates, there was a remarkable reduction in the extent of vascular smooth muscle coverage in mutant embryos compared to wild type (E,F).

Copyright

This image is from Fritz-Six KL, J Clin Invest 2008 Jan;118(1):40-50 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:130930

Associated Alleles

Symbol	Name
Ramp2^tm1Kmca	receptor (calcitonin) activity modifying protein 2; targeted mutation 1, Kathleen Caron

Associated Genotypes

Allelic Composition	Genetic Background
Ramp2^tm1Kmca/Ramp2^tm1Kmca	involves: 129S6/SvEvTac * C57BL/6