Phenotype Image Detail

Image

Caption

A: Eyelids from a 2 day old wild type mouse. f, fused eyelid epidermis; c, cornea. B: Eyelids from Dsc1^tm1Dga/Dsc1^tm1Dga littermate showing a failure of eyelid fusion, inflammation, and corneal damage. t, eyelid tips which have failed to fuse. C: Flaky skin in two mutant mice at 2 days old. At this age, mutant mice were indistinguishable in size from their normal littermates. D: Flaky skin and characteristic runted appearance in an 8 day old mutant mouse (bottom) when compared with a wild type littermate (top). E: Delayed weight gain in mutant mice. Results from a typical litter consisting of nine pups in which a mutant (Nu) mouse and its wild type (No) littermates were born with equal weights, but at weaning (21 days) the mutant mouse weighed 30% less than the average of the others. Bars represent range of weights of normal littermates. 10 litters were examined with similar results. Bars, 150um.

Copyright

This image is from Chidgey M, J Cell Biol 2001 Nov 26;155(5):821-32, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:73102

Associated Alleles

Symbol	Name
Dsc1^tm1Dga	desmocollin 1; targeted mutation 1, David R Garrod

Associated Genotypes

Allelic Composition	Genetic Background
Dsc1^tm1Dga/Dsc1^tm1Dga	involves: C57BL/6J