Phenotype Image Detail

Image

Caption

Histology and immunohistochemistry of Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo and wild type mice. Cross-sections of the facial skin of wild type (A,D and J), young Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo (B,E and K) and aged mutant (C,F,G,H,I and L) mice. Low power views (A-c) and corresponding high power views (D-F) of hematoxylin and eosin stained section. The skin of the young mutant mouse had mononuclear epidermal and dermal infiltrates and moderate acanthosis and hyperkeratosis (B and E). The aged mutant mouse had more severe and expanded inflammatory infiltrates containing numerous eosinphils in the skin and subcutaneous tissues (C and F). Acanthosis, parakeratosis, and hyperkeratosis were prominent in the aged mutant mouse. Immunohistochemistry demonstrated that the mononuclear epidermal infiltrate of aged mutant mice consisted of CD4⁺ T cells (G), CD8⁺ T cells (H), and MHC class II positive Langerhans-like cells that were dendritic in shape (I). B220-positive B cells and acid-phosphatase-positive macrophages were absent in the inflamed epidermis. The numbers of mast cells in the facial skin of normal controls (J) and young mutants (K) were similar; however, numerous mast cells had infiltrated into chronic eczematous lesions of aged mutant mice (L). Toluidine-blue stained sections (J-L). Magnification: A-C, x30; D-I, x150; and J-L x60.

Copyright

This image is from Shiina T, J Biol Chem 2004 Dec 31;279(53):55493-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:95040

Associated Alleles

Symbol	Name
Nfkbiz^tm1Mamo	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; targeted mutation 1, Masami Morimatsu

Associated Genotypes

Allelic Composition	Genetic Background
Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo	involves: 129S7/SvEvBrd