Phenotype Image Detail

Image

Caption

Ultrastructural analysis of podocytes from control and Lmx1b^tm1Rjo/Lmx1b^tm1Rjo mice. Low and high-magnification micrographs from control (a and b) and Lmx1b^tm1Rjo/Lmx1b^tm1Rjo (d and e) mice show reduced foot process formation in the mutant. Those processes that do form have aberrant cell-cell junctions (f, arrows). Normal and aberrant processes and junctions have been schematized for clarity (insets in b and f). Mutant podocytes resemble those observed in immature control glomeruli (c), suggesting that mutant podocytes are developmentally arrested. P, podocyte; rbc, red blood cell; E, endothelial cell; arrowheads, foot processes. Bar: a, c, and d, 2.3um; b, e and f, 0.7um.

Copyright

This image is from Miner JH, J Clin Invest 2002 Apr;109(8):1065-72 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:76089

Associated Alleles

Symbol	Name
Lmx1b^tm1Rjo	LIM homeobox transcription factor 1 beta; targeted mutation 1, Randy L Johnson

Associated Genotypes

Allelic Composition	Genetic Background
Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	Not Specified