Phenotype Image Detail

Image

Caption

Ultrastructural analysis of diaphragm muscle and heart architecture of wild type and Ldb3^tm1Chen/Ldb3^tm1Chen mice. Representative images from diaphragm muscle of E17.5 and day 1 neonatal (N1) wild type (+/+) and Ldb3^tm1Chen/Ldb3^tm1Chen (-/-) mice (A-D). A comparison of diaphragm muscle from wild type and mutant mice at E17.5, when diaphragm muscle is inactive, shows well-preserved Z-line and M-line structure (A and B). In contrast, Z-lines in diaphragm muscle from mutant mice at postnatal day 1 are severely disorganized and disrupted; M-lines, however, are relatively normal (C and D). Representative images from cardiac muscle of E17.5 and day 1 neonatal wild type and mutant mice (E-H). In embryonic cardiac muscle, Z-lines are evident, but distinct, well-formed M-lines are not yet present. In mutant mice, E17.5 cardiac muscle, which has been functional since E 8, exhibits fragmented and disorganized Z-lines (E and F). In postnatal day 1 cardiac muscle of wild type mice, both Z-lines and M-lines are well formed and distinctly visible. In contrast, only remnants of the Z-lines and not M-lines are visible in cardiac muscle from mutant mice (G and H). Bar, 1.5um.

Copyright

This image is from Zhou Q, J Cell Biol 2001 Nov 12;155(4):605-12, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:72799

Associated Alleles

Symbol	Name
Ldb3^tm1Chen	LIM domain binding 3; targeted mutation 1, Ju Chen

Associated Genotypes

Allelic Composition	Genetic Background
Ldb3^tm1Chen/Ldb3^tm1Chen	involves: 129S1/Sv * 129X1/SvJ * Black Swiss