Phenotype Image Detail

Image

Caption

Histology of Lama4^tm1Ktry/Lama4^tm1Ktry and control hearts at 40 weeks of age. A-D: Hematoxylin and eosin staining of cryostat section of hearts from a 40 week old Lama4^tm1Ktry/Lama4^tm1Ktry (Lama4-/-) mouse (B,D) and its littermate control (A,C), showing interstitial fibrosis and cardiomyocyte degeneration in mutant mice (B,D). E-H: Electron microscopy picture of mutant heart (F,H) and its littermate wild type control heart (E,G) at the age of 4 weeks, showing widening of intercellular and perivascular space, and dilated and deformed blood vessels (F,H); bv, blood vessel; cm, cardiomyocyte; arrows, perivascular space; *, cardiomyocyte degeneration and fibrosis. Scale bars, A-D, 100um; E and F, 10um; G and H, 5um.

Copyright

This image is from Wang J, J Biol Chem 2006 Jan 6;281(1):213-20 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:105789

Associated Alleles

Symbol	Name
Lama4^tm1Ktry	laminin, alpha 4; targeted mutation 1, Karl Tryggvason

Associated Genotypes

Allelic Composition	Genetic Background
Lama4^tm1Ktry/Lama4^tm1Ktry	B6.129X1-Lama4^tm1Ktry