Phenotype Image Detail

Image

Caption

A: Gomori trichrom staining of cryostat section of the heart from a Lama4^tm1Ktry/Lama4^tm1Ktry mouse showing multiple foci of fibrosis in right and left ventricular wall, interventricular septum, right and left atria, and A-V node region (arrows). B: High power magnification of A-V node region showing cardiomyocyte degeneration and fibrosis. C: Enzyme histochemical staining for acetylcholine esterase to highlight the A-V node (AVN). D: High power magnification of a degenerative region from interventricular septum (IVS) showing cardiomyocyte degeneration and fibrosis. Scale bars: B-D, 100um.

Copyright

This image is from Wang J, J Biol Chem 2006 Jan 6;281(1):213-20 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:105789

Associated Alleles

Symbol	Name
Lama4^tm1Ktry	laminin, alpha 4; targeted mutation 1, Karl Tryggvason

Associated Genotypes

Allelic Composition	Genetic Background
Lama4^tm1Ktry/Lama4^tm1Ktry	B6.129X1-Lama4^tm1Ktry