Phenotype Image Detail

Image

Caption

Radiographs of 30 day old wild type (wt) and Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc (ko) mice. Top row shows hind limb, pelvis and vertebrae. Insets show higher magnification of the proximal tibia. (Lower) Skulls hemisected in the midline. Marrow cavities are absent in the osteopetrotic mutant mouse. The cartilage growth plate, seen as a radiolucent stripe across the proximal tibia in the mutant mouse (arrow) is thicker in the mutant mouse. Incisors, evident in the wild type, fail to erupt in the mutant (arrowhead), as do the molars.

Copyright

This image is from Kim N, Proc Natl Acad Sci U S A 2000 Sep 26;97(20):10905-10. Copyright 2000 National Academy of Sciences, U.S.A. J:64737

Associated Alleles

Symbol	Name
Tnfsf11^tm1Ywc	tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1, Yongwon Choi

Associated Genotypes

Allelic Composition	Genetic Background
Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc	involves: 129P2/OlaHsd