Phenotype Image Detail

Image

Caption

Histology of the bone marrow (BM) microenvironment of nonirradiated Ptpn2^tm1Mtr/Ptpn2^tm1Mtr mice. Analysis of BM was performed on 21 day old mice. A: Stromal cells (arrrows) are attached to, or clustered between bone trabeculae in control mice. B: By contrast, a marked paucity of stromal cells is observed in the BM of mutant mice in those areas normally rich in stromal cells. The hematopoietic cell population is comparable in both groups of mice. Periodic-acid Schiff stain; original magnification: x150.

Copyright

This image is from You-Ten KE, J Exp Med 1997 Aug 29;186(5):683-93, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:42595

Associated Alleles

Symbol	Name
Ptpn2^tm1Mtr	protein tyrosine phosphatase, non-receptor type 2; targeted mutation 1, Michel L Tremblay

Associated Genotypes

Allelic Composition	Genetic Background
Ptpn2^tm1Mtr/Ptpn2^tm1Mtr	involves: 129S4/SvJae * BALB/c