Phenotype Image Detail

Image

Caption

Electron micrographs of brain capillaries in wild type (A and C) and Pdgfb^tm1Cbet/Pdgfb^tm1Cbet (PDGFB-/-, B and D-H) embryos at E18.5. Capillaries in wild type embryonic brains exhibited a smooth luminal and abluminal endothelial surface and a homogeneous thickness of the endothelium (A and C), whereas those in mutant embryos were of highly variable thickness (B and D). Luminal microfolds greatly enlarged the endothelial surface (D), and perivascular glial swelling was prominent (star in D). Caveolae were abundant in the endothelium of mutant embryos (E-H), both near the luminal (arrows) and the abluminal surface (boxed area, enlarged in G and H). In G, a series of caveolae appeared almost to connect the luminal and the abluminal compartment. Bars: A and B, 10um; C-F, 1um; G and H, 100nm.

Copyright

This image is from Hellstrom M, J Cell Biol 2001 Apr 30;153(3):543-53, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:78912

Associated Alleles

Symbol	Name
Pdgfb^tm1Cbet	platelet derived growth factor, B polypeptide; targeted mutation 1, Christer Betsholtz

Associated Genotypes

Allelic Composition	Genetic Background
Pdgfb^tm1Cbet/Pdgfb^tm1Cbet	involves: 129P2/OlaHsd * C57BL/6