Phenotype Image Detail

Image

Caption

A: Toluidine blue stained, Epon-embedded sections from 1 month old wild type (wt) mice. B-C: Osteoclasts (red) visualized by TRAP histochemistry on similarly oriented sections from wild type and Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc (ko) mice. Key areas of osteoclast activity in growing long bones are indicated by numbers 1-4 in A, and represent: 1, lower margin of epiphysis; 2, chondroosseous junction; 3, ends of metaphyseal trabeculae; and 4, metaphyseal periosteum. Osteoclasts are found in all four areas in wild type (B). No osteoclasts are present in mutant mice (C). Marrow cavities (m) are seen in wild type but not in mutant mice. Magnification: A-C, x205.

Copyright

This image is from Kim N, Proc Natl Acad Sci U S A 2000 Sep 26;97(20):10905-10. Copyright 2000 National Academy of Sciences, U.S.A. J:64737

Associated Alleles

Symbol	Name
Tnfsf11^tm1Ywc	tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1, Yongwon Choi

Associated Genotypes

Allelic Composition	Genetic Background
Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc	involves: 129P2/OlaHsd