Phenotype Image Detail

Image

Caption

Comparison of remodeling of diaphyseal cortical bone in wild type (wt) and Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc (ko) mice. Periosteal surface is toward the top and endosteum toward the bottom in both panels. The mutant mice show typical osteopetrotic woven bone that has never been remodeled, with mineralized cartilage cores (c, purple) covered by bone (blue). Normal remodeled, lamellar bone (L) lacking cartilage cores is seen in wild type diaphyses, with healthy, cuboidal osteoblasts (*) lining the endosteal bone surface, osteocytes in lacunae (arrows), and active marrow (m). Toluidine-blue-stained, 1um Epon sections, tibial diaphyses of 30 day old mice. Magnification, x1300.

Copyright

This image is from Kim N, Proc Natl Acad Sci U S A 2000 Sep 26;97(20):10905-10. Copyright 2000 National Academy of Sciences, U.S.A. J:64737

Associated Alleles

Symbol	Name
Tnfsf11^tm1Ywc	tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1, Yongwon Choi

Associated Genotypes

Allelic Composition	Genetic Background
Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc	involves: 129P2/OlaHsd