Phenotype Image Detail

Image

Caption

Histology of embryonic and adult hearts. C-F: Hematoxylin and eosin stained sectons of wild-type (+/+, C and D) and Ccn3^tm1Cabo/Ccn3^tm1Cabo (-/-, E and F) E13.5 embryonic hearts showing abnormal expansion of the endocardial cushions (EC) and delay in fusion of the septum (S) in the mutant mouse (arrow). G-M: Hematoxylin and eosin stained sections of wild-type (G and J) and mutant (H,I and K) adult hearts, showing accumulation of blood in the sub-endothelial space between the right ventricle and the septum (H) and hypertrophy of the septum near the origins of the great vessels (H,I and K). Areas of calcification on the septal wall of the right ventricle (K and L), stain with Von Kossa (M). There is no associated fibrosis. Scale bar: D and F, 20um; C and E. 50um; G,H and I, 1mm; J and K, 50um; M, 5um.

Copyright

This image is from Heath E, BMC Dev Biol 2008;8():18, an open-access article, licensee BioMed Central Ltd. J:135676

Associated Alleles

Symbol	Name
Ccn3^tm1Cabo	cellular communication network factor 3; targeted mutation 1, Catherine A Boulter

Associated Genotypes

Allelic Composition	Genetic Background
Ccn3^tm1Cabo/Ccn3^tm1Cabo	involves: 129S/SvEv