Phenotype Image Detail

Image

Caption

Phenotype of subcutaneous and hypaxial muscles. B and C: Photographs of wild type (+/+, B) and Ccn3^tm1Cabo/Ccn3^tm1Cabo (-/-, C) body walls, showing thinning and transparency in the mutant. D-I: Hematoxylin and eosin stained sections of adult skin from wild-type (D and G), Ccn3^tm1Cabo/Nov⁺ (+/-, E and H), and Ccn3^tm1Cabo/Ccn3^tm1Cabo (F and I) mice showing atrophy of subcutaneous muscles in heterozygous and homozygous mice, with arrowheads marking the residual muscle layer. Histology of the subcutaneous adipose tissue in wild-type (J) and homozygous (K) mice showing large mature fat cells in the wild-type in contrast to the mixture of large (mature) and small (immature) fat cells in the mutant. L and M: Hematoxylin and eosin stained section of adult intercostal muscles in wild-type (L) and homozygous mutant (M) mice showing muscle atrophy and transdifferentiation to fat in the mutant. Scale bars: D-F, 50um; G-M, 10um.

Copyright

This image is from Heath E, BMC Dev Biol 2008;8():18, an open-access article, licensee BioMed Central Ltd. J:135676

Associated Alleles

Symbol	Name
Ccn3^tm1Cabo	cellular communication network factor 3; targeted mutation 1, Catherine A Boulter

Associated Genotypes

Allelic Composition	Genetic Background
Ccn3^tm1Cabo/Ccn3^+	involves: 129S/SvEv
Ccn3^tm1Cabo/Ccn3^tm1Cabo	involves: 129S/SvEv