Phenotype Image Detail

Image

Caption

A: Bone marrow fibrosis in Stim1^Sax/Stim1⁺ (Stim1^Sax/+) mice. Hematoxylin and eosin (top and middle rows) and Gomori stainings (bottom row) of femural bone marrow of wild-type (WT) and heterozygous mice at different ages. Note the increased collagen deposition and bone marrow destruction in the mutant mice. B: Increased spleen size in 6 month old mutant mice. C: Effacement of the red/white pulp architecture and increased numbers of mature megakaryocytes (MK) in spleens from 6 month old mutant mice. Cryosections were stained with anti-GPIb antibodies (red) and counterstained with hematoxylin. Total cell numbers (D) and leukocyte composition (E) in spleens from 6 month old wild-type (black bars) and mutant (white bars) mice. F: A 4 day thrombopoietin (TPO) treatment caused a significant elevation of platelet counts in wild-type but not in mutant mice. d0, before treatment. n=4 per group; paired Student's t test, P<0.001. Mean +/- SD.

Copyright

This image is from Grosse J, J Clin Invest 2007 Nov;117(11):3540-50 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:127381

Associated Alleles

Symbol	Name
Stim1^Sax	stromal interaction molecule 1; Saxcoburggotski

Associated Genotypes

Allelic Composition	Genetic Background
Stim1^Sax/Stim1^+	involves: C3HeB/FeJ * C57BL/6