Phenotype Image Detail

Image

Caption

A: Gross anatomy of spleens from wild-type (+/+, top), Sh2b3^tm1Paw/Sh2b3⁺ (+/-, middle) and Sh2b3^tm1Paw/Sh2b3^tm1Paw (-/-, bottom) mice. B and C: Low power magnification (10x) of hematoxylin and eosin staining of splenic sections from wild-type (B) and homozygous mutant (C) mice showing enlargement of the white (W) and red (R) pulp. D-G: Cryosections of spleens from wild-type (D and F) and mutant mice (E and G) stained with anti-B220 (red, D and E), anti-Ter119 (red, F and G), and anti-CD41 (green, F and G)-conjugated antibodies. Magnification: D and E, 50x; F and G, 200x.

Copyright

This image is from Velazquez L, J Exp Med 2002 Jun 17;195(12):1599-611, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:77248

Associated Alleles

Symbol	Name
Sh2b3^tm1Paw	SH2B adaptor protein 3; targeted mutation 1, Tony Pawson

Associated Genotypes

Allelic Composition	Genetic Background
Sh2b3^tm1Paw/Sh2b3^tm1Paw	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)