Phenotype Image Detail

Image

Caption

Histologic analysis of skeletal muscle of Sgcg^tm1Mcn/Sgcg^tm1Mcn mice. A-C: Masson Trichrome staining of muscle. A: Low-power view of diaphragm muscle from wild-type (+/+) and Sgcg^tm1Mcn/Sgcg^tm1Mcn (-/-) mice. Of note, the magnification is equal in the two photos. Diaphragm tissue from mutant mice was hypertrophied. Marked replacement by connective and adipose tissue is seen throughout the diaphragm of mutant muscle. Areas of calcification are visible. B: Low-power magnification of mutant quadriceps muscle (right) shows regions of inflammatory infiltrate adjacent to normal appearing muscle. Scale bar, 100 um. C: High power view of guadriceps muscle showing an area of infiltrate and regeneration. D: Immunostaining of muscle plasma membrane with an anti-dystrophin antibody counterstained with DAPI to reveal centrally placed nuclei seen in mutant muscle. Scale bar, 25 um.

Copyright

This image is from Hack AA, J Cell Biol 1998 Sep 7;142(5):1279-87, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:49871

Associated Alleles

Symbol	Name
Sgcg^tm1Mcn	sarcoglycan, gamma (dystrophin-associated glycoprotein); targeted mutation 1, Elizabeth M McNally

Associated Genotypes

Allelic Composition	Genetic Background
Sgcg^tm1Mcn/Sgcg^tm1Mcn	involves: 129X1/SvJ * C57BL/6