Phenotype Image Detail

Image

Caption

A and B: Masson trichrome-stained hearts taken from 20 week old wild type (+/+, B) and Sgcg^tm1Mcn/Sgcg^tm1Mcn (-/-, A) littermates. Bar, 625um. Lv, left ventricle; RV, right ventricle. A: A representative mutant heart with significant increases in right and left ventricular wall thickness. C: The region within the box of A. The mutant heart shown in A shows marked fibrosis, seen as blue staining. Wall thickness of the right ventricle is markedly increased (A); the right ventricular cavity is marked with an asterisk. Bar, 100um. D: A higher magnification view of perivascular fibrosis is seen. Bar, 25um.

Copyright

This image is from Hack AA, J Cell Biol 1998 Sep 7;142(5):1279-87, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:49871

Associated Alleles

Symbol	Name
Sgcg^tm1Mcn	sarcoglycan, gamma (dystrophin-associated glycoprotein); targeted mutation 1, Elizabeth M McNally

Associated Genotypes

Allelic Composition	Genetic Background
Sgcg^tm1Mcn/Sgcg^tm1Mcn	involves: 129X1/SvJ * C57BL/6