Phenotype Image Detail

Image

Caption

Ultrastructural study of wild-type and Fbn1^Tsk/Fbn1⁺ mice skin. A,C, and E, Normal wild type mouse; B,D and F, Fbn1^Tsk/Fbn1⁺ mouse. A and B are low power views (5,000x) showing basal keratinocytes, the dermo-epidermal junction as represented by the lamina densa (open arrows), and the upper dermis. In both mice, the dermis is dominated by collagen bundles. Microfibrillar bundles and elastic fibers are indicated by closed arrows. B reveals the presence of larger microfibrillar bundles with abundant microfibrils but little elastin. C-F are high magnification views of elastic fibers and microfibrillar bundles. These appear less well defined in mutant skin (D and F) than in wild-type skin (C and E). In particular, the striation pattern of microfibrils (arrowheads) seen with the wild-type mice (C and E) was less apparent in the mutant skin. Bars: A and B, 3,000 nm; C-F, 250 nm.

Copyright

This image is from Kielty CM, J Cell Biol 1998 Mar 9;140(5):1159-66, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:46405

Associated Alleles

Symbol	Name
Fbn1^Tsk	fibrillin 1; tight skin

Associated Genotypes

Allelic Composition	Genetic Background
Fbn1^Tsk/Fbn1^+	B6.Cg-Fbn1^Tsk