Phenotype Image Detail

Image

Caption

The phenotype of S1P receptor null embryos. The following embryos were analyzed at E12.5: A, wild type (WT); B, S1pr1^tm1Rlp/S1pr1^tm1Rlp (S1P 1^-/-); C, S1pr1^tm1Rlp/S1pr1⁺ S1pr3^tm1Rlp/S1pr3^tm1Rlp (S1P 1^+/- S1P 3^-/-); D, S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp (S1P 1^-/- S1P 3^-/-); E, S1pr2^tm1Rlp/S1pr2^tm1Rlp (SIP 1^+/+ S1P 2^-/-); F, S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp (S1P 1^-/- S1P 2^-/-). In panel B the S1pr1^tm1Rlp/S1pr1^tm1Rlp embryo shows bleeding along the body and head (arrowheads) and underdeveloped limbs (arrow). The S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp embryo in panel D shows a phenotype similar to that of the S1pr1^tm1Rlp/S1pr1^tm1Rlp embryo. In panel F, the S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp embryo shows a more severe bleeding phenotype than does the single S1pr1^tm1Rlp/S1pr1^tm1Rlp embryo.

Copyright

This image is from Kono M, J Biol Chem 2004 Jul 9;279(28):29367-73 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:106055

Associated Alleles

Symbol	Name
S1pr1^tm1Rlp	sphingosine-1-phosphate receptor 1; targeted mutation 1, Richard L Proia
S1pr2^tm1Rlp	sphingosine-1-phosphate receptor 2; targeted mutation 1, Richard L Proia
S1pr3^tm1Rlp	sphingosine-1-phosphate receptor 3; targeted mutation 1, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
S1pr1^tm1Rlp/S1pr1^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6
S1pr2^tm1Rlp/S1pr2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6
S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6
S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6