Phenotype Image Detail

Image

Caption

Histological analysis of S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp embryos. A: Littermate control S1pr2^tm1Rlp/S1pr2⁺ S1pr3^tm1Rlp/S1pr3^tm1Rlp (S1P 2^+/- S1P 3^-/-) embryo at E13.5. B: S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp (S1P 1^-/- S1P 3^-/-) double homozygous mutant embryos were sectioned transversely at the thoracic level and stained by hematoxylin and eosin. The double mutant embryo shows hemorrhage and edema in the subcutaneous region (brackets in panels A and B). C and D: Electron microscopic analysis of microvessels in E14.5 double mutant embryos. The double mutant endothelial cells were abnormally thin (arrowheads in panel C) and broken (arrows in panels C and D). Scale bars: A and B, 200um; C and D, 1um.

Copyright

This image is from Kono M, J Biol Chem 2004 Jul 9;279(28):29367-73 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:106055

Associated Alleles

Symbol	Name
S1pr2^tm1Rlp	sphingosine-1-phosphate receptor 2; targeted mutation 1, Richard L Proia
S1pr3^tm1Rlp	sphingosine-1-phosphate receptor 3; targeted mutation 1, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
S1pr3^tm1Rlp/S1pr3^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6