Phenotype Image Detail

Image

Caption

Morphology of the epidermis of Cldn1^tm1Sts/Cldn1^tm1Sts mice. B: Hematoxylin and eosin stained sectional images obtained from the back of wild-type (+/+) and Cldn1^tm1Sts/Cldn1^tm1Sts (-/-) newborns. The epidermis of mutant newborn mice did not exhibit overt abnormalities in the layered organization of keratinocytes except that stratum corneum appeared to be thicker and compacted tighter than that of the wild-type epidermis. Sc, stratum corneum; GR, stratum granulosum; SP, stratum spinosum; BL, stratum basale. Scale bar: 20um. C: Ultrathin section electron microscope images of skin obtained from the back of wild-type and mutant newborns. The appearance of individual keratinocytes was indistinguishable between wild-type and mutant skin. Scale bars: 0.5um.

Copyright

This image is from Furuse M, J Cell Biol 2002 Mar 18;156(6):1099-111, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:75447

Associated Alleles

Symbol	Name
Cldn1^tm1Sts	claudin 1; targeted mutation 1, Shoichiro Tsukida

Associated Genotypes

Allelic Composition	Genetic Background
Cldn1^tm1Sts/Cldn1^tm1Sts	involves: 129S4/SvJae * C57BL/6