Phenotype Image Detail

Image

Caption

Transplantation of the Cldn1^tm1Sts/Cldn1^tm1Sts skin to nude mice. A: Macroscopic images of the skin grafts on nude mice at 1 month after transplantation from newborns. The wild-type (+/+) grafts bore numerous long hairs, whereas the Cldn1^tm1Sts/Cldn1^tm1Sts (-/-) grafts had only a small number of short hairs (left). When hairs were cropped, the mutant grafts appeared to be thicker than the wild-type grafts, and in some places they appeared to be covered with infiltrates (right). B: Hematoxylin and eosin stained sectional images of the skin grafts on nude mice at 1 month after transplantation from newborns. The epidermis of the mutant grafts was unusually thick compared with that of the wild-type grafts, although hair follicles appeared to be developed even in the mutant grafts. Scale bar: 100um.

Copyright

This image is from Furuse M, J Cell Biol 2002 Mar 18;156(6):1099-111, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:75447

Associated Alleles

Symbol	Name
Cldn1^tm1Sts	claudin 1; targeted mutation 1, Shoichiro Tsukida

Associated Genotypes

Allelic Composition	Genetic Background
Cldn1^tm1Sts/Cldn1^tm1Sts	involves: 129S4/SvJae * C57BL/6