Phenotype Image Detail

Image

Caption

Histological analysis of cardiac cells in Ppara^tm1Gonz/Ppara^tm1Gonz and wild-type mice. A: Light microscopy. The myocardium of the wild-type mouse (a and d) at the age of 32 weeks seemed to be normal. The myocardium of the Ppara^tm1Gonz/Ppara^tm1Gonz mouse at the age of 16 weeks (b and e) showed a little focal fibrosis. In the mutant mouse at 32 weeks (c and f), diffuse dense fibrosis was evident in the myocardium. Fibrosis (arrows) is stained blue with Azan-Mallory staining (f). HE, hematoxylin and eosin stain. Original magnification, x100. B: Electron microscopy. Upper panels show mitochondria in the myocardial cells. The wild-type mouse at the age of 32 weeks (A). The mutant mouse at the age of 16 weeks (B) and 32 weeks (C). Cristae increased in number and density in the mutant mouse. Lower panels show caveolae in the cardiac capillary endothelial cells. The wild-type mouse at the age of 32 weeks (D). The caveolae in mutant mouse at the age of 16 weeks (E) and 32 weeks (F) were more numerous than those in the wild-type mouse (D). Bar = 1um.

Copyright

This image is from Watanabe K, J Biol Chem 2000 Jul 21;275(29):22293-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:63801

Associated Alleles

Symbol	Name
Ppara^tm1Gonz	peroxisome proliferator activated receptor alpha; targeted mutation 1, Frank J Gonzalez

Associated Genotypes

Allelic Composition	Genetic Background
Ppara^tm1Gonz/Ppara^tm1Gonz	involves: 129S4/SvJae