Phenotype Image Detail

Image

Caption

A: Structurally abnormal sperm tails in Vdac3^tm1Wjc/Vdac3^tm1Wjc male mice. Shown is an electron micrograph of axonemes from epididymal sperm of wild-type (VDAC3(+/+), C) (x10,000) and mutant (VDAC3(-/-), A) (x13,000). The arrows indicate the position of the missing microtubules. The lower panels show lengthwise images (x6,000) of the midpiece of elongating spermatids, demonstrating the enlarged, disordered mitochondria of mutant spermatids (B) in comparison with the orderly spiral of mitochondria from wild-type spermatids (D). B: Tracheal cilia are strucutrally normal. The top panels show cross-sections through tracheal epithelial cilia from wild-type (A) and mutant mice (B) (x26.000). The bottom panel shows representative scanning electron micrographs (x2000) from the same tracheal epithelia. Note the paucity of ciliated cells from mutant mice (D).

Copyright

This image is from Sampson MJ, J Biol Chem 2001 Oct 19;276(42):39206-12 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:72188

Associated Alleles

Symbol	Name
Vdac3^tm1Wjc	voltage-dependent anion channel 3; targeted mutation 1, Willam J Craigen

Associated Genotypes

Allelic Composition	Genetic Background
Vdac3^tm1Wjc/Vdac3^tm1Wjc	Not Specified