Phenotype Image Detail

Image

Caption

A: Gated cardiac magnetic resonance imaging (MRI). Representative short axis (transverse) images at the mid-level of wild-type (WT) and Cav3^tm1Mls/Cav3^tm1Mls (Cav-3 KO) mice during diastole. Arrows point to the left ventricle. Note that the left ventricle wall thickness is increased significantly in mutant mice. LV, left ventricle. B: Graphic representation. A bar graph of the left ventricular wall thickness of mutant hearts at 2 and 4 months of age is shown and compared with age-matched wild-type control mice. Note the progressive increases in mutant left ventricle wall thickness from 2 to 4 months (n=5 for each group tested, p <0.05).

Copyright

This image is from Woodman SE, J Biol Chem 2002 Oct 11;277(41):38988-97 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:79453

Associated Alleles

Symbol	Name
Cav3^tm1Mls	caveolin 3; targeted mutation 1, Michael P Lisanti

Associated Genotypes

Allelic Composition	Genetic Background
Cav3^tm1Mls/Cav3^tm1Mls	involves: 129/Sv * C57BL/6J * SJL