Phenotype Image Detail

Image

Caption

Histological examination of Cav3^tm1Mls/Cav3^tm1Mls heart tissue reveals cardiac myocyte hypertrophy, interstitial/peri-vascular fibrosis and cellular infiltrates. Representative hematoxylin and eosin staining of wild-type (WT, A and B) and Cav3^tm1Mls/Cav3^tm1Mls (Cav-3 KO, D and E) heart pariffin-embedded sections is shown. Note the marked hypertrophic cardiac myocytes (arrows) and cellular infiltrates (arrowheads) in the mutant sample. Trichrome staining of 11 month old wild-type (C) and mutant (F) hearts reveals increased interstitial/peri-vasuclar fibrosis at the junction of the right and left ventricles in mutant hearts at this age.

Copyright

This image is from Woodman SE, J Biol Chem 2002 Oct 11;277(41):38988-97 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:79453

Associated Alleles

Symbol	Name
Cav3^tm1Mls	caveolin 3; targeted mutation 1, Michael P Lisanti

Associated Genotypes

Allelic Composition	Genetic Background
Cav3^tm1Mls/Cav3^tm1Mls	involves: 129/Sv * C57BL/6J * SJL
Cav3^tm1Mls/Cav3^tm1Mls	FVB.Cg-Cav3^tm1Mls