Phenotype Image Detail

Image

Caption

Wild-type (A) embryo at E12.5 reveals yolk sac with well developed blood islands, while Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr littermate (B) is smaller in size with fewer blood islands in its yolk sac (ys). C: External appearance of eye, blood-enriched liver, and distal part of hind limb with separated fingers (white arrow) in wild-type embryo. B: Mutant embryo shows dilated leaking small vessels (white arrowhead) and few large blood vessels. Pigmented tissue is thinner in the dorsal portion of the eye (ey). The liver (li) mass is small and pale in the mutant embryo. Finger separation does not occur in the distal part of hind limb (white arrow). Each pair of photographs was taken at the same magnification.

Copyright

This image is from Zhu YJ, J Biol Chem 2003 Jan 17;278(3):1986-90 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:81217

Associated Alleles

Symbol	Name
Ncoa6^tm1.1Jkr	nuclear receptor coactivator 6; targeted mutation 1.1, Janardan K Reddy

Associated Genotypes

Allelic Composition	Genetic Background
Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr	involves: 129P2/OlaHsd * C57BL/6 * FVB/N