Phenotype Image Detail

Image

Caption

A and B: Histological analysis of sagittal sections of heart ventricle from E12.5 wild-type (A) and Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr (B) embryos. Trabeculation (t) is less extensive in mutant embryo than in the wild-type littermate. The compact layer (cl) of the mutant is significantly thinner. Epicardium (ep) is mutant is separated from underlying myocardium. In some regions of compact layer of the mutant, the adhesion of myocytes was disrupted and red blood cells penetrated through myocardium (arrowheads). C and D: PCNA staining for the proliferating cells in ventricles of E12.5 wild-type (C) and mutant (D) embryos. Fewer dark brown PCNA-positive cells are present in the compact layer of the mutant ventricle.

Copyright

This image is from Zhu YJ, J Biol Chem 2003 Jan 17;278(3):1986-90 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:81217

Associated Alleles

Symbol	Name
Ncoa6^tm1.1Jkr	nuclear receptor coactivator 6; targeted mutation 1.1, Janardan K Reddy

Associated Genotypes

Allelic Composition	Genetic Background
Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr	involves: 129P2/OlaHsd * C57BL/6 * FVB/N