Phenotype Image Detail

Image

Caption

Hematoxylin and eosin staining of liver sections from wild-type and Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr embryos. At low magnification, liver (li) in Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr (B) embryo is greatly reduced in size than that of wild-type liver (A). Liver of mutant contains large numbers of megakaryocytes (white arrowhead), fewer of erythroid progenitors (black arrowhead), and many cells with apoptotic bodies (white arrowhead), in contrast to the normal liver (C). The inset in D shows a closer view of the apoptotic cells in liver of mutant embryo.

Copyright

This image is from Zhu YJ, J Biol Chem 2003 Jan 17;278(3):1986-90 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:81217

Associated Alleles

Symbol	Name
Ncoa6^tm1.1Jkr	nuclear receptor coactivator 6; targeted mutation 1.1, Janardan K Reddy

Associated Genotypes

Allelic Composition	Genetic Background
Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr	involves: 129P2/OlaHsd * C57BL/6 * FVB/N